Nutrient sensing
How Rag GTPases help cells translate nutrient availability into decisions about growth and metabolism.
Understanding how cells decide to grow.
I’m Šárka Doležalová, a Ph.D. researcher in David Sabatini Lab. My work explores nutrient sensing, cell-growth regulation, and the molecular context that can change everything.
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About
Research at the scale of a cell
Small molecular switches. Far-reaching biological questions.
I’m a Ph.D. researcher trained in molecular biology and biochemistry at Charles University. My research interests sit at the intersection of cell signaling, metabolism, and cancer biology.
My doctoral research investigates the nutrient-sensing Rag GTPases and the proteins they may interact with—part of the molecular machinery that helps a cell determine when conditions are right to grow.
This first edition uses identity-matched academic information from the supplied research review. Publication and profile details will be expanded after final author verification.
Current interests
Questions I return to
Three connected perspectives on how cells sense their environment, regulate growth, and change their behavior.
Cell-cycle context
How the same regulatory protein can suppress or support cancer depending on localization, modification, and cellular context.
Protein interactions
Using biochemical experiments to investigate the molecular partnerships behind complex signaling pathways.
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Curriculum vitae
Education & experience
Academic path
PDF CV
Download will be added after final review.
2026 — Present
Ph.D. research · Cell growth regulation
IOCB Prague · Sabatini Group
Doctoral research investigating proteins that may interact with nutrient-sensing Rag GTPases, including co-immunoprecipitation-based approaches.
Completed 2026
M.Sc. · Genetics, Molecular Biology & Virology
Charles University · Faculty of Science
Completed a specialization in molecular biology and genetics of eukaryotes. Her thesis focused on novel targets of nutrient-sensing Rag GTPases.
Completed 2024
B.Sc. · Molecular Biology & Biochemistry
Charles University · Faculty of Science
Bachelor’s work examined the context-dependent roles of cyclin-dependent kinase inhibitors in cancer biology.
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Teaching
Learning with curiosity
Children & young people educator
I have always enjoyed sharing knowledge and helping young people discover that learning can be both rewarding and exciting.
I tutor mathematics, physics, chemistry, biology, and Czech, and prepare students for high-school entrance exams as well as admissions to university programs in science and medicine.
What I enjoy most is helping students understand the ideas behind what they are learning rather than simply memorizing facts. Mathematics, in particular, has a beautiful puzzle-like logic—the satisfaction of breaking down a difficult problem and finding a solution is something I love passing on to others.
Education is not only about gaining knowledge, but also about developing curiosity, confidence, and the ability to think independently.
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Academic work
Selected research
Theses & publications
Verified records and full-text copies of my academic work are linked below through the Charles University Digital Repository.
Identification of novel targets of the nutrient sensing Rag GTPases
Experimental investigation of candidate interaction partners in a central cellular nutrient-sensing pathway.
Charles University · Faculty of Science · defended 25 May 2026 · English
Context-dependent roles of cyclin-dependent kinase inhibitors (CDKi) in cancer
A review of how post-translational context can alter the role of cell-cycle inhibitors in cancer progression.
Charles University · Faculty of Science · defended 4 June 2024 · Czech
Exploring Biologically Relevant Cation-pi Interactions in Water
Neutron-scattering research data deposited with the Institut Laue-Langevin. The dataset is registered with a DOI and remains under embargo.
Červenka, Doležalová, Duboué-Dijon, Fischer, Kantin, Mason, Shanks & Taly · Institut Laue-Langevin · DIR-442
Notes from the bench
Research journal
A future home for explainers, reflections, and field notes—written for scientists and curious readers alike.
Lab notes · template
01When the data challenges the hypothesis
A future note on why unexpected results are often where the most interesting questions begin.
Coming soonExplainer · template
02How a cell decides whether to grow
A plain-language guide to nutrient sensing, mTORC1, lysosomes, and the tiny molecular switches between them.
Coming soonField notes · template
03Life at the bench in Prague
Short observations on learning new methods, asking better questions, and building a life in science.
Coming soonConnect
Science grows through conversation.
For research connections, collaborations, and updates, find me on LinkedIn. A direct contact address will be added after the site’s final profile review.
Connect on LinkedIn